Early overnutrition alters synaptic signaling and induces leptin resistance in arcuate proopiomelanocortin neurons
نویسندگان
چکیده
منابع مشابه
Early overnutrition results in early-onset arcuate leptin resistance and increased sensitivity to high-fat diet.
Childhood obesity increases the risk of adult obesity and diabetes, suggesting that early overnutrition permanently programs altered energy and glucose homeostasis. In the present studies, we used a mouse model to investigate whether early overnutrition increases susceptibility to obesity and insulin resistance in response to a high-fat diet (HFD). Litters from Swiss Webster dams were culled to...
متن کاملSynaptic regulation of proopiomelanocortin neurons can occur distal to the arcuate nucleus.
Energy homeostasis is controlled to a large extent by various signals that are integrated in the hypothalamus. It is generally considered that neurons in each of the hypothalamic nuclei are regulated by afferent projections that terminate within the cell body region of the nucleus. However, here it is shown that hypothalamic proopiomelanocortin (POMC) neurons receive synaptic inputs onto distal...
متن کاملLoss of leptin receptors on hypothalamic POMC neurons alters synaptic
32 Adaptive changes in hypothalamic neural circuitry occur in response to alterations in 33 nutritional status. This plasticity at hypothalamic synapses contributes to the control of food 34 intake and body weight. Here we show that genetic ablation of leptin receptor gene 35 expression in POMC neurons (POMC: Lepr GFP) induces alterations at synapses on 36 POMC neurons in the arcuate nucleus of...
متن کاملDivergent regulation of proopiomelanocortin neurons by leptin in the nucleus of the solitary tract and in the arcuate hypothalamic nucleus.
Proopiomelanocortin (POMC) neurons in the arcuate nucleus (ARC) of the hypothalamus are activated by leptin and mediate part of leptin's central actions to influence energy balance. However, little is known about potential leptin signaling in POMC neurons located in the nucleus of the solitary tract (NTS), the only other known population of POMC neurons. Leptin-responsive neurons do exist in th...
متن کاملAcute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.
Normal food intake and body weight homeostasis require the direct action of leptin on hypothalamic proopiomelanocortin (POMC) neurons. It has been proposed that leptin action requires PI3K activity. We therefore assessed the contribution of PI3K signaling to leptin's effects on POMC neurons and organismal energy balance. Leptin caused a rapid depolarization of POMC neurons and an increase in ac...
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ژورنال
عنوان ژورنال: Physiology & Behavior
سال: 2019
ISSN: 0031-9384
DOI: 10.1016/j.physbeh.2019.04.002